产品名称
SLIK1 Rabbit Polyclonal Antibody
基因名称
SLITRK1 KIAA1910 LRRC12 UNQ233/PRO266
蛋白名称
SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96PX8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96PX8/entry
Mouse Swissprot No.
Q810C1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q810C1
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
SLIK1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
组织表达
Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
细胞定位
Membrane ; Single-pass type I membrane protein . Secreted . Cell junction, synapse .
功能
developmental stage:At 20 weeks of gestation, expressed in multiple brain regions, including the developing neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus.,disease:Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities.,function:Enhances neuronal dendrite outgrowth.,similarity:Belongs to the SLITRK family.,similarity:Contains 13 LRR (leucine-rich) repeats.,tissue specificity:Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, gliobastomas, gangliogliomas and primitive neuroectodermal tumors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
