产品名称
NR4A2 Rabbit Polyclonal Antibody
基因名称
NR4A2 NOT NURR1 TINUR
蛋白名称
Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P43354
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P43354/entry
Mouse Swissprot No.
Q06219
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q06219
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q07917
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
NR4A2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
细胞定位
Cytoplasm. Nucleus. Mostly nuclear; oxidative stress promotes cytoplasmic localization.
功能
developmental stage:Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.,function:Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the protein in the brain, indicates that it is not mandatorily associated with cell cycle progression.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
