产品名称
FLRT2 Rabbit Polyclonal Antibody
基因名称
FLRT2 KIAA0405 UNQ232/PRO265
蛋白名称
Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43155
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43155/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
FLRT2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
fibronectin leucine rich transmembrane protein 2(FLRT2) Homo sapiens This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016],
组织表达
Expressed in pancreas, skeletal muscle, brain, and heart.
细胞定位
Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane . Cell junction, focal adhesion . Secreted, extracellular space, extracellular matrix . Microsome membrane . Secreted . Cell junction, synapse, synaptosome . Proteolytic cleavage gives rise to a shedded ectodomain. .
功能
function:May have a function in cell adhesion and/or receptor signaling.,PTM:N-glycosylated.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in pancreas, skeletal muscle, brain, and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
