BD-PE5254

TP53I3 (PIG3) (14V12) Mouse Monoclonal antibody

常规抗体

TP53I3

WB

Human

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

Full length human recombinant protein of human TP53I3(NP_671713) produced in HEK293T cell.

WB 1:2000

35.4kDa

-20°C/1 year

Mouse

IgG1

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

现货

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)