产品名称
WASL Rabbit Polyclonal Antibody
蛋白名称
Neural Wiskott-Aldrich syndrome protein (N-WASP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00401
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00401/entry
Mouse Swissprot No.
Q91YD9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91YD9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O08816
免疫原
Synthesized peptide derived from human protein . at AA range: 190-270
特异性
WASL Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013],
细胞定位
Cytoplasm, cytoskeleton . Nucleus . Cytoplasm . Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity). .
信号通路
Chemokine;Adherens_Junction;Fc gamma R-mediated phagocytosis;Regulates Actin and Cytoskeleton;Pathogenic Escherichia coli infection;
功能
function:Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 WH1 domain.,similarity:Contains 2 WH2 domains.,subcellular location:Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.,subunit:Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
