产品名称
RYK Rabbit Polyclonal Antibody
蛋白名称
Tyrosine-protein kinase RYK (EC 2.7.10.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P34925
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P34925/entry
Mouse Swissprot No.
Q01887
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01887
免疫原
Synthesized peptide derived from human protein . at AA range: 150-230
特异性
RYK Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms
组织表达
Observed in all the tissues examined.
细胞定位
Membrane ; Single-pass type I membrane protein . Nucleus . Cytoplasm . In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Potential growth factor receptor protein tyrosine kinase.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 WIF domain.,tissue specificity:Observed in all the tissues examined.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
