产品名称
VMAT2 Rabbit Polyclonal Antibody
蛋白名称
Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q05940
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q05940/entry
Mouse Swissprot No.
Q8BRU6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BRU6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q01827
免疫原
Synthesized peptide derived from human protein . at AA range: 1-80
特异性
VMAT2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],
组织表达
Brain,Platelet,Substantia nigra,Testis,
细胞定位
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
信号通路
Parkinson's disease;
功能
function:Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.,online information:Vesicular monoamine transporter entry,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
