产品名称
NAAA Rabbit Polyclonal Antibody
蛋白名称
N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q02083
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q02083/entry
Mouse Swissprot No.
Q9D7V9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D7V9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5KTC7
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
NAAA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
细胞定位
Lysosome . Membrane ; Peripheral membrane protein .
功能
enzyme regulation:Stimulated by DTT and Nonidet P-40.,function:Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.,PTM:N-glycosylated. Tunicamycin treatment causes a reduction in specific activity against N-palmitoylethanolamine.,similarity:Belongs to the acid ceramidase family.,tissue specificity:Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.