BD-PN2298

PEAR1 Rabbit Polyclonal Antibody

常规抗体

PEAR1 MEGF12

Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

375033

Q5VY43

https://www.uniprot.org/uniprotkb/Q5VY43/entry

Q8VIK5

http://www.uniprot.org/uniprot/Q8VIK5

Synthesized peptide derived from human protein . at AA range: 910-990

PEAR1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

114kD

-20°C/1 year

Polyclonal, Rabbit,IgG

PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008],

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

Cell membrane ; Single-pass membrane protein . Detected on the cell surface in resting platelets. .

function:When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.,PTM:Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.,similarity:Belongs to the MEGF family.,similarity:Contains 1 EMI domain.,similarity:Contains 9 EGF-like domains.,subcellular location:Detected on the cell surface in resting platelets.,subunit:Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.,tissue specificity:Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and veine, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blodd leukocytes and macrophages.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.