产品名称
STC2 Rabbit Polyclonal Antibody
蛋白名称
Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O76061
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O76061/entry
Mouse Swissprot No.
O88452
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88452
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9R0K8
免疫原
Synthesized peptide derived from human protein . at AA range: 170-250
特异性
STC2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008],
组织表达
Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
功能
function:Has an anti-hypocalcemic action on calcium and phosphate homeostasis.,similarity:Belongs to the stanniocalcin family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood Leucocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
