产品名称
TYY1 Rabbit Polyclonal Antibody
蛋白名称
Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P25490
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P25490/entry
Mouse Swissprot No.
Q00899
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q00899
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
TYY1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Foreskin,Lymph,
细胞定位
Nucleus matrix . Associated with the nuclear matrix.
功能
function:Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. May play an important role in development and differentiation. The function of YY1 as an activator or a repressor is specified by the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.,similarity:Belongs to the YY transcription factor family.,similarity:Contains 4 C2H2-type zinc fingers.,subcellular location:Associated with the nuclear matrix.,subunit:Interacts with YAF2 through the region encompassing the first and second zinc fingers. Interacts with INO80.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
