产品名称
TNR19 Rabbit Polyclonal Antibody
基因名称
TNFRSF19 TAJ TROY UNQ1888/PRO4333
蛋白名称
Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NS68
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NS68/entry
Mouse Swissprot No.
Q9JLL3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JLL3
免疫原
Synthesized peptide derived from human protein . at AA range: 20-100
特异性
TNR19 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
细胞定位
Membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.,tissue specificity:Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
