产品名称
TNR14 Rabbit Polyclonal Antibody
基因名称
TNFRSF14 HVEA HVEM UNQ329/PRO509
蛋白名称
Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92956
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92956/entry
免疫原
Synthesized peptide derived from human protein . at AA range: 190-270
特异性
TNR14 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
组织表达
Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.,PTM:N-glycosylated.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Interacts with TRAF2, TRAF3 and TRAF5.,tissue specificity:Widely expressed, with the highest expression in lung, spleen and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
