产品名称
HIP1R Rabbit Polyclonal Antibody
基因名称
HIP1R HIP12 KIAA0655
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9026
Human Swissprot No.
O75146
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75146/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29816
Mouse Swissprot No.
Q9JKY5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKY5
免疫原
Synthesized peptide derived from human HIP1R AA range: 554-604
特异性
This antibody detects endogenous levels of HIP1R at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
细胞定位
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
功能
domain:The talin-like domain binds F-actin.,function:Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.,similarity:Belongs to the SLA2 family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.,subunit:Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1.,tissue specificity:Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
