产品名称
TRY2 Rabbit Polyclonal Antibody
蛋白名称
Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P07478
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P07478/entry
Mouse Swissprot No.
P07146
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07146
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P00763
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
TRY2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],
组织表达
Expressed in Paneth cells, at the base of small intestinal crypts.
细胞定位
Secreted, extracellular space.
信号通路
Neuroactive ligand-receptor interaction;
功能
catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
