BD-PE4787-CCM2 (3M19) Mouse Monoclonal antibody-现货抗体产品库武汉枢密脑科学技术有限公司

CCM2 (3M19) Mouse Monoclonal antibody

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产品基本信息

产品货号

BD-PE4787

产品名称

CCM2 (3M19) Mouse Monoclonal antibody

类别

常规抗体

基因名称

CCM2

推荐应用

反应种属

Human,Mouse,Rat

存储缓冲液

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

免疫原

Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

稀释度

WB 1:500~2000, IHC 1:150

预测分子量

48.7kDa

运输及保存条件

-20°C/1 year

宿主

Mouse

同种型

IgG1

背景介绍

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

期货

现货

纯化

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CCM2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CCM2(Cat# BD-PE4787). Positive lysates (100ug) and (20ug) can be purchased separately from OriGene.

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE4787)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE4787)

Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE4787)

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-CCM2 monoclonal antibody.

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE4787)

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE4787)