产品名称
VAMP1 Rabbit Polyclonal Antibody
蛋白名称
Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P23763
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23763/entry
Mouse Swissprot No.
Q62442
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62442
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63666
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
VAMP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],
组织表达
Nervous system, skeletal muscle and adipose tissue.
细胞定位
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 2]: Cytoplasmic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein .
信号通路
SNARE interactions in vesicular transport;
功能
function:Involved in the targeting and/or fusion of transport vesicles to their target membrane.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subunit:Interacts with VAPA and VAPB.,tissue specificity:Nervous system, skeletal muscle and adipose tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
