产品名称
DPP6 Rabbit Polyclonal Antibody
蛋白名称
Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P42658
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P42658/entry
Mouse Swissprot No.
Q9Z218
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z218
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P46101
免疫原
Synthesized peptide derived from human protein . at AA range: 750-830
特异性
DPP6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
组织表达
Expressed predominantly in brain.
细胞定位
Cell membrane ; Single-pass type II membrane protein .
功能
disease:Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.,function:May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2.,similarity:Belongs to the peptidase S9B family.,subunit:Homodimer. Binds KCND2.,tissue specificity:Expressed predominantly in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
