产品名称
GFRA2 Rabbit Polyclonal Antibody
基因名称
GFRA2 GDNFRB RETL2 TRNR2
蛋白名称
GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00451
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00451/entry
Mouse Swissprot No.
O08842
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08842
免疫原
Synthesized peptide derived from human protein . at AA range: 320-400
特异性
GFRA2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
组织表达
Isoform 1 is found in both brain and placenta.
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor .
功能
function:Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.,similarity:Belongs to the GDNFR family.,tissue specificity:Isoform 1 is found in both brain and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
