产品名称
HEPS Rabbit Polyclonal Antibody
蛋白名称
Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P05981
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P05981/entry
Mouse Swissprot No.
O35453
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35453
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q05511
免疫原
Synthesized peptide derived from human protein . at AA range: 350-430
特异性
HEPS Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
组织表达
Detected in liver and kidney.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Apical cell membrane ; Single-pass type II membrane protein .
功能
catalytic activity:Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.,function:Plays an essential role in cell growth and maintenance of cell morphology.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,tissue specificity:Present in most tissues, with the highest level in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
