产品名称
KRA14 Rabbit Polyclonal Antibody
基因名称
KRTAP1-4 KAP1.4 KRTAP1.4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/728255
Human Swissprot No.
P0C5Y4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P0C5Y4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/23927
Mouse Swissprot No.
O08640
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08640
免疫原
Synthesized peptide derived from human KRA14 AA range: 5-55
特异性
This antibody detects endogenous levels of KRA14 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009],
组织表达
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
功能
function:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the KRTAP type 1 family.,subunit:Interacts with hair keratins.,tissue specificity:Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
