产品名称
RAP1B Rabbit Polyclonal Antibody
蛋白名称
Ras-related protein Rap-1b (GTP-binding protein smg p21B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P61224
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P61224/entry
Mouse Swissprot No.
Q99JI6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99JI6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62636
免疫原
Synthesized peptide derived from human protein . at AA range: 110-190
特异性
RAP1B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011],
组织表达
Amygdala,Brain,Chondrosarcoma,Colon adenocarcinoma,Placenta,Platele
细胞定位
Cell membrane . Cytoplasm, cytosol . Cell junction . May shuttle between plasma membrane and cytosol (PubMed:3141412). Presence of KRIT1 and CDH5 is required for its localization to the cell junction (PubMed:20332120). .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Chemokine;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;Neurotrophin;Renal cell carcinoma;
功能
enzyme regulation:Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:May shuttle between plasma membrane and cytosol.,subunit:Interacts with SGSM1, SGSM2 and SGSM3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
