产品名称
CHSTF Rabbit Polyclonal Antibody
基因名称
CHST15 BRAG GALNAC4S6ST KIAA0598
蛋白名称
Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7LFX5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7LFX5/entry
Mouse Swissprot No.
Q91XQ5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XQ5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8CHI9
免疫原
Synthesized peptide derived from human protein . at AA range: 440-520
特异性
CHSTF Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
组织表达
Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein . A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
信号通路
Chondroitin sulfate biosynthesis;
功能
monosaccharide metabolic process,?carbohydrate biosynthetic process,?hexose metabolic process,?hexose biosynthetic process,?cellular carbohydrate biosynthetic process,?alcohol biosynthetic process,?monosaccharide biosynthetic process,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
