产品名称
NR1D2 Rabbit Polyclonal Antibody
蛋白名称
Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14995
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14995/entry
Mouse Swissprot No.
Q60674
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60674
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63504
免疫原
Synthesized peptide derived from part region of human protein
特异性
NR1D2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009],
组织表达
Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.
细胞定位
Nucleus . Cytoplasm . Phosphorylation by CSNK1E enhances its cytoplasmic localization. .
功能
function:Binds to the sequences 5'-AATGTAGGTCA-3' and 5'-ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR alpha function.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NCOA5 coactivator, leading to a strong increase of transcription of target genes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
