产品名称
ANTR1 Rabbit Polyclonal Antibody
蛋白名称
Anthrax toxin receptor 1 (Tumor endothelial marker 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H6X2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H6X2/entry
Mouse Swissprot No.
Q9CZ52
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZ52
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q0PMD2
免疫原
Synthesized peptide derived from part region of human protein
特异性
ANTR1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008],
组织表达
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). .
功能
alternative products:Experimental confirmation may be lacking for some isoforms,domain:Binding to PA seems to be effected through the VWA domain.,function:Cellular role is not yet known.,similarity:Belongs to the ATR family.,similarity:Contains 1 VWFA domain.,subunit:Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.,tissue specificity:Highly expressed in tumor endothelial cells but not in normal endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
