产品名称
PON2 Rabbit Polyclonal Antibody
蛋白名称
Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15165
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15165/entry
Mouse Swissprot No.
Q62086
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62086
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6AXM8
免疫原
Synthesized peptide derived from part region of human protein
特异性
PON2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with highest expression in liver, lung, placenta, testis and heart.
细胞定位
Membrane ; Peripheral membrane protein .
功能
catalytic activity:A phenyl acetate + H(2)O = a phenol + acetate.,catalytic activity:An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.,function:Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters (By similarity). Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.,online information:The Singapore human mutation and polymorphism database,PTM:Glycosylated.,PTM:The signal sequence is not cleaved.,similarity:Belongs to the paraoxonase family.,tissue specificity:Widely expressed with highest expression in liver, lung, placenta, testis and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
