产品名称
LIPA4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8497
Human Swissprot No.
O75335
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75335/entry
Rat Gene Link
https://www.uniprot.org/uniprot/140592
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z80
免疫原
Synthesized peptide derived from human LIPA4 AA range: 513-563
特异性
This antibody detects endogenous levels of LIPA4 at Human/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008],
组织表达
Expressed only in the heart, brain, and skeletal muscle.
细胞定位
Cytoplasm . Cell surface . Colocalizes with PTPRF at the cell surface. .
功能
domain:The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.,function:May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.,similarity:Belongs to the liprin family. Liprin-alpha subfamily.,similarity:Contains 3 SAM (sterile alpha motif) domains.,subcellular location:Colocalizes with PTPRF at the cell surface.,subunit:Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, GIT1, KIF1A and GRIP1.,tissue specificity:Expressed only in the heart, brain, and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
