产品名称
PRDX6 Rabbit Polyclonal Antibody
蛋白名称
Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Liver 2D page spot 40) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (Red blood cells page spot 12)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P30041
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30041/entry
Mouse Swissprot No.
O08709
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08709
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O35244
免疫原
Synthesized peptide derived from part region of human protein
特异性
PRDX6 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Cajal-Retzius cell,Erythrocyte,Fetal brain,Fetal brain cortex,Liver,Plate
细胞定位
Cytoplasm . Lysosome . Also found in lung secretory organelles (lamellar bodies). .
信号通路
Phenylalanine metabolism;Methane metabolism;
功能
catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,function:Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.,miscellaneous:Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.,miscellaneous:The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,similarity:Belongs to the ahpC/TSA family. Rehydrin subfamily.,similarity:Contains 1 thioredoxin domain.,subcellular location:And also found in lung secretory organelles.,subunit:Homotetramer. May interact with HTR2A (By similarity). Interacts with STH.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
