产品名称
CLC1B Rabbit Polyclonal Antibody
基因名称
CLEC1B CLEC2 UNQ721/PRO1384
蛋白名称
C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9P126
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P126/entry
Mouse Swissprot No.
Q9JL99
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JL99
免疫原
Synthesized peptide derived from part region of human protein
特异性
CLC1B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011],
组织表达
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
细胞定位
Membrane ; Single-pass type II membrane protein .
功能
function:Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.,online information:CLEC-2,PTM:Glycosylated.,PTM:Phosphorylated on tyrosine residue in response to rhodocytin binding.,similarity:Contains 1 C-type lectin domain.,subunit:Monomer.,tissue specificity:Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
