产品名称
LYVE1 Rabbit Polyclonal Antibody
基因名称
LYVE1 CRSBP1 HAR XLKD1 UNQ230/PRO263
蛋白名称
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5Y7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5Y7/entry
Mouse Swissprot No.
Q8BHC0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BHC0
免疫原
Synthesized peptide derived from part region of human protein
特异性
LYVE1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008],
组织表达
Mainly expressed in endothelial cells lining lymphatic vessels.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. Localizes at cell-cell junctions.
功能
function:Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.,PTM:O-glycosylated.,similarity:Contains 1 Link domain.,subcellular location:Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.,subunit:Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.,tissue specificity:Mainly expressed in endothelial cells lining lymphatic vessels.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
