产品名称
DDC Rabbit Polyclonal Antibody
蛋白名称
Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P20711
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20711/entry
Mouse Swissprot No.
O88533
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88533
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P14173
免疫原
Synthesized peptide derived from part region of human protein
特异性
DDC Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
dopa decarboxylase(DDC) Homo sapiens The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011],
组织表达
[Isoform 2]: High expression in kidney.
细胞定位
cytosol,synaptic vesicle,axon,neuronal cell body,extracellular exosome,
信号通路
Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Tryptophan metabolism;
功能
catalytic activity:3,4-dihydroxy-L-phenylalanine = dopamine + CO(2).,catalytic activity:5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).,cofactor:Pyridoxal phosphate.,disease:Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.,function:Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.,online information:Aromatic L-amino-acid decarboxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
