产品名称
ESX1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80712
Human Swissprot No.
Q8N693
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N693/entry
免疫原
Synthesized peptide derived from human ESX1 AA range: 327-377
特异性
This antibody detects endogenous levels of ESX1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010],
组织表达
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
细胞定位
Cytoplasm . Nucleus . ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
功能
similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in placenta and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
