产品名称
LFTY1 Rabbit Polyclonal Antibody
基因名称
LEFTY1 LEFTB LEFTYB UNQ278/PRO317
蛋白名称
Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75610
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75610/entry
Mouse Swissprot No.
Q64280
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64280
免疫原
Synthesized peptide derived from part region of human protein AA range: 121-170
特异性
LFTY1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],
组织表达
Colon,Pancreas,Spleen,Teratocarcinoma,
功能
function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
