产品名称
PORIM Rabbit Polyclonal Antibody
基因名称
TMEM123 KCT3 PSEC0111 UNQ641/PRO1271
蛋白名称
Porimin (Keratinocytes-associated transmembrane protein 3) (KCT-3) (Pro-oncosis receptor inducing membrane injury) (Transmembrane protein 123)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N131
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N131/entry
Mouse Swissprot No.
Q91Z22
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91Z22
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5HZB0
免疫原
Synthesized peptide derived from part region of human protein
特异性
PORIM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
function:Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.,similarity:Belongs to the CD164 family.,tissue specificity:Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
