产品名称
TNR27 Rabbit Polyclonal Antibody
基因名称
EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080
蛋白名称
Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HAV5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HAV5/entry
Mouse Swissprot No.
Q8BX35
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BX35
免疫原
Synthesized peptide derived from part region of human protein
特异性
TNR27 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016],
细胞定位
Membrane; Single-pass type III membrane protein.
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF3 and TRAF6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
