产品名称
OSCAR Rabbit Polyclonal Antibody
蛋白名称
Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IYS5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IYS5/entry
Mouse Swissprot No.
Q8VBT3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VBT3
免疫原
Synthesized peptide derived from part region of human protein
特异性
OSCAR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
细胞定位
[Isoform 1]: Secreted .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.,similarity:Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
