产品名称
ECE2 Rabbit Polyclonal Antibody
基因名称
ECE2 KIAA0604 UNQ403/PRO740
蛋白名称
Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O60344
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60344/entry
Mouse Swissprot No.
Q80Z60
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80Z60
免疫原
Synthesized peptide derived from part region of human protein
特异性
ECE2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
Brain,Clones donated by RIKEN,Lung,Ovary,Thalamus,
细胞定位
Golgi membrane,integral component of membrane,cytoplasmic vesicle membrane,
功能
catalytic activity:Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.,cofactor:Binds 1 zinc ion per subunit.,function:Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.,similarity:In the C-terminal section; belongs to the peptidase M13 family.,similarity:In the N-terminal section; belongs to the methyltransferase superfamily.,tissue specificity:Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disase patients (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
