产品名称
AIF1 Rabbit Polyclonal Antibody
蛋白名称
Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P55008
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55008/entry
Mouse Swissprot No.
O70200
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70200
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P55009
免疫原
Synthesized peptide derived from part region of human protein
特异性
AIF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016],
组织表达
Detected in T-lymphocytes and peripheral blood mononuclear cells.
细胞定位
Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, phagocytic cup . Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. .
功能
function:May play a role in macrophage activation and function.,PTM:Phosphorylated on serine residues.,similarity:Contains 2 EF-hand domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
