产品名称
TNR27 Rabbit Polyclonal Antibody
基因名称
EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080
蛋白名称
Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HAV5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HAV5/entry
Mouse Swissprot No.
Q8BX35
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BX35
免疫原
Synthesized peptide derived from part region of human protein
特异性
TNR27 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016],
细胞定位
Membrane; Single-pass type III membrane protein.
信号通路
Cytokine-cytokine receptor interaction;
功能
function:Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Associates with TRAF1, TRAF3 and TRAF6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
