产品名称
NR1H4 Rabbit Polyclonal Antibody
基因名称
NR1H4 BAR FXR HRR1 RIP14
蛋白名称
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96RI1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96RI1/entry
Mouse Swissprot No.
Q60641
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60641
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62735
免疫原
Synthesized peptide derived from part region of human protein
特异性
NR1H4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016],
组织表达
Liver and hepatocyte-related cells express mainly FXRalpha1-type isoforms with isoform 3 and isoform 4 in approximately equal proportions. In intestine and kidney mainly FXRalpha2-type isoforms are expressed with isoform 1 and isoform 2 in approximately equal proportions. Expressed in pancreatic beta cells and macrophages.
细胞定位
Nucleus .; [Isoform 1]: Nucleus .; [Isoform 2]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 4]: Nucleus .
功能
function:Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus.,online information:Farnesoid X receptor entry,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
