产品名称
OSCAR Rabbit Polyclonal Antibody
蛋白名称
Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IYS5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IYS5/entry
Mouse Swissprot No.
Q8VBT3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VBT3
免疫原
Synthesized peptide derived from part region of human protein
特异性
OSCAR Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013],
细胞定位
[Isoform 1]: Secreted .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.,similarity:Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
