产品名称
CART Rabbit Polyclonal Antibody
蛋白名称
Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39); CART(42-89)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16568
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16568/entry
Mouse Swissprot No.
P56388
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56388
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P49192
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
CART Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016],
组织表达
Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.
功能
disease:A defect in CART is associated with reduced resting energy expenditure and cosegregates with obesity phenotype.,function:Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.,induction:By leptin.,similarity:Belongs to the CART family.,tissue specificity:Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
