产品名称
ERAP2 Rabbit Polyclonal Antibody
蛋白名称
Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6P179
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P179/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
ERAP2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016],
组织表达
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
功能
cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.,induction:By IFN-gamma.,miscellaneous:Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M1 family.,subunit:Heterodimer; with ERAP1.,tissue specificity:Ubiquitously expressed. Highly expressed in spleen and leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
