产品名称
SPIT2 Rabbit Polyclonal Antibody
蛋白名称
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43291
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43291/entry
Mouse Swissprot No.
Q9WU03
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WU03
免疫原
Synthesized peptide derived from part region of human protein
特异性
SPIT2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
组织表达
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
domain:This inhibitor contains two inhibitory domains.,function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.,similarity:Contains 1 BPTI/Kunitz inhibitor domain.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,tissue specificity:Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
