产品名称
FCRL1 Rabbit Polyclonal Antibody
基因名称
FCRL1 FCRH1 IFGP1 IRTA5
蛋白名称
Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96LA6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96LA6/entry
Mouse Swissprot No.
Q8R4Y0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4Y0
免疫原
Synthesized peptide derived from part region of human protein
特异性
FCRL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
组织表达
Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
function:May function as an activating coreceptor in B cells. May function in B cells activation and differentiation.,induction:Down-regulated in activated B cells.,PTM:Phosphorylated on tyrosines upon activation.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
