产品名称
SHBG Rabbit Polyclonal Antibody
蛋白名称
Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P04278
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04278/entry
Mouse Swissprot No.
P97497
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97497
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P08689
免疫原
Synthesized peptide derived from part region of human protein
特异性
SHBG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
组织表达
Isoform 1 and isoform 2 are present in liver and testis.
细胞定位
Secreted . In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. .
功能
alternative products:Additional isoforms seem to exist,function:Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.,online information:Androgen-binding protein entry,similarity:Contains 2 laminin G-like domains.,subcellular location:In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.,subunit:Homodimer.,tissue specificity:Isoforms 1 and 2 are present in liver and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
