产品名称
MMEL1 Rabbit Polyclonal Antibody
基因名称
MMEL1 MELL1 MMEL2 NEP2
蛋白名称
Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q495T6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q495T6/entry
Mouse Swissprot No.
Q9JLI3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JLI3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P0C1T0
免疫原
Synthesized peptide derived from part region of human protein
特异性
MMEL1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
细胞定位
Membrane; Single-pass type II membrane protein. Secreted. A secreted form produced by proteolytic cleavage also exists. .
功能
catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by thiorphan and phosphoramidon.,function:Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,subcellular location:A secreted form produced by proteollytic cleavage also exists.,tissue specificity:Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
