产品名称
DKK2 Rabbit Polyclonal Antibody
蛋白名称
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBU2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBU2/entry
Mouse Swissprot No.
Q9QYZ8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYZ8
免疫原
Synthesized peptide derived from part region of human protein
特异性
DKK2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart, brain, skeletal muscle and lung.
功能
function:Inhibitor of Wnt signaling pathway .,PTM:May be proteolytically processed by a furin-like protease.,similarity:Belongs to the dickkopf family.,tissue specificity:Expressed in heart, brain, skeletal muscle and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
