产品名称
BRAC Rabbit Polyclonal Antibody
蛋白名称
Brachyury protein (Protein T)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15178
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15178/entry
Mouse Swissprot No.
P20293
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20293
免疫原
Synthesized peptide derived from part region of human protein AA range: 181-230
特异性
BRAC Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],
组织表达
Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level).
功能
disease:Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.,function:Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.,similarity:Contains 1 T-box DNA-binding domain.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
