产品名称
MSMB Rabbit Polyclonal Antibody
蛋白名称
Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P08118
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08118/entry
Mouse Swissprot No.
O08540
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08540
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97580
免疫原
Synthesized peptide derived from part region of human protein AA range: 61-110
特异性
MSMB Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.
细胞定位
Secreted. Sperm surface.
功能
caution:Was originally thought to inhibit the secretion of FSH by pituitary cells.,disease:A genetic variation in MSMB is associated with susceptibility to hereditary prostate cancer type 13 (HPC13) [MIM:611928].,miscellaneous:Specific receptors for this protein are found on spermatozoa and in the prostate.,similarity:Belongs to the beta-microseminoprotein family.,subcellular location:Sperm surface.,subunit:Interacts with PI16.,tissue specificity:Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
