产品名称
CARF Rabbit Polyclonal Antibody
蛋白名称
CDKN2A-interacting protein (Collaborator of ARF)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NXV6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NXV6/entry
Mouse Swissprot No.
Q8BI72
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BI72
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5U2X0
免疫原
Synthesized peptide derived from part region of human protein
特异性
CARF Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus, nucleoplasm .
功能
function:Activates TP53/p53 by CDKN2A-dependent and CDKN2A-independent pathways.,PTM:May be ubiquitinated.,similarity:Belongs to the CARF family.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subunit:Interacts with CDKN2A/p14ARF, TP53/p53 and MDM2.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
